Every Contribution Matters

Research is vital in increasing our understanding of HD, improving the quality of life for those impacted by HD, and also providing hope for viable treatments and a cure.

Research continues to progress through the collaboration between you-our community, our invaluable HD researchers and your association. When you participate in research, your contribution not only helps in the study you are involved in, but is often a starting point for new or further research.

Huntington’s Victoria proudly partners with the Huntington’s Research Group of Victoria (HRGV) who are extremely active in HD research. You can view some of the local research below, and find out how you can become involved.

Featured Researchers

Pubu Abeyasinghe (Pubuditha Abeyasinghe)

Pubu Abeyasinghe (Pubuditha Abeyasinghe)

EXPLORING COMPUTATIONAL MODELLING TO PREDICT DISEASE PROGRESSION IN HUNTINGTON’S DISEASE USING COMBINED IMAGE-HD, PREDICT-HD AND TRACK-HD DATASETS

Research Date: 07/10/2019

Details:
Applications of computational modeling in Huntington’s disease is a promising avenue in research directing towards predicting the disease progression. In the past few years, researchers have shown the positive impacts of modeling the disease progression to find the most sensitive biomarkers not only in Huntington’s disease but also in other neurodegenerative disease such as Alzheimer’s’ disease. We are interested in applying computational modeling techniques to the combined data sets from IMAG-HD, PREDICT-HD and TRACK-HD studies to find a model that could explain the disease progression across studies with high accuracy. In the process of developing the model we aim explore and incorporate not only the clinical measures but also the behavioral and imaging measures and find the best combination of measures that results in the highest predictability of disease progression. These modelling techniques will be crucial to understand the level of contribution of each measure to disease progression which then can be used in the advancement of developing more effective treatment methods or therapeutical approaches targeting the most sensitive measures, to delay the neural degeneration and the subsequent onset of the Huntington’s disease.

For further information about the study including eligibility and participation requirements please contact:
Pubu Abeyasinghe
Address:
Turner Institute for Brain and Mental Health
Room 425,  18 Innovation Walk
Monash University, Clayton VIC 3800

 

Dr Carolina Gubert

Dr Carolina Gubert

EXPLORING THE GUT MICROBIOME AND GENE-ENVIRONMENT INTERACTIONS IN HUNTINGTON’S DISEASE: TOWARDS NOVEL THERAPEUTIC APPROACHES TO DELAY DISEASE ONSET AND PROGRESSION

Research Date: 01/01/2019

Details:
Our laboratory has extensively contributed to our understanding of gene-environment interactions in Huntington’s disease (HD), including the beneficial effects of cognitive stimulation and physical activity. Environmental enrichment and exercise interventions mimics a stimulating lifestyle, which has been shown to positively impact different neurodegenerative conditions, including HD, where Anthony Hannan and colleagues made the original discoveries. These approaches have been able to ameliorate neurodegenerative phenotype, emotionality-related behaviours and cognitive effects in HD transgenic mice. We are interested in this project to understand the promising actions of these interventions on the differential gut microbial profile (microbiome) presented in HD mice, also previously discovered by the Hannan Laboratory at the Florey Institute. To achieve this goal, we use cognitive and behavioural tasks, as well as genetics, genomics and bioinformatics tools.  These results will be crucial to our understanding of the physiological role of these environmental interventions on gut microbial profile in HD, and will help us identify new therapeutic targets to delay onset and progression of this devastating disease.

For further information about this research please contact:
Dr Carolina Gubert
Phone: +61 3 9035 5569
Address:
Hannan Laboratory, Florey Institute of Neuroscience and Mental Health

 

 Brendan McLaren

Brendan McLaren

REMOTE ASSESSMENT OF COGNITION, SLEEP, AND PHYSICAL ACTIVITY IN EARLY HUNTINGTON'S DISEASE.

Research Date: 01/02/2015

Details:
The project is focused on developing technologies that allow greater community participation in Huntington’s disease (HD) research. We are also investigating how the thinking skills of people with HD are affected by how much exercise they do and how well they sleep. We have developed HD mobile, a smartphone application that measures the thinking skills of people who have, or are at risk of developing, HD. HD-Mobile provides HD-community members, regardless of geographical location, the opportunity to participate in HD research. The project will also increase our understanding of how lifestyle (e.g., sleep and exercise) can be managed to boost thinking the performance of people with, or at risk of developing, HD.

For further information about the study including eligibility and participation requirements please contact:
Brendan McLaren
Phone: 9905 3958
Address:
Room 408, Level 4, 18 Innovation Walk
Monash University, Clayton VIC 3800

 

Local Research: