Every Contribution Matters
Research is vital in increasing our understanding of HD, improving the quality of life for those impacted by HD, and also providing hope for viable treatments and a cure.
Research continues to progress through the collaboration between you-our community, our invaluable HD researchers and your association. When you participate in research, your contribution not only helps in the study you are involved in, but is often a starting point for new or further research.
Huntington’s Victoria proudly partners with the Huntington’s Research Group of Victoria (HRGV) who are extremely active in HD research. You can view some of the local research below, and find out how you can become involved.
Pubu Abeyasinghe (Pubuditha Abeyasinghe)
EXPLORING COMPUTATIONAL MODELLING TO PREDICT DISEASE PROGRESSION IN HUNTINGTON’S DISEASE USING COMBINED IMAGE-HD, PREDICT-HD AND TRACK-HD DATASETS
Research Date: 07/10/2019
Applications of computational modeling in Huntington’s disease is a promising avenue in research directing towards predicting the disease progression. In the past few years, researchers have shown the positive impacts of modeling the disease progression to find the most sensitive biomarkers not only in Huntington’s disease but also in other neurodegenerative disease such as Alzheimer’s’ disease. We are interested in applying computational modeling techniques to the combined data sets from IMAG-HD, PREDICT-HD and TRACK-HD studies to find a model that could explain the disease progression across studies with high accuracy. In the process of developing the model we aim explore and incorporate not only the clinical measures but also the behavioral and imaging measures and find the best combination of measures that results in the highest predictability of disease progression. These modelling techniques will be crucial to understand the level of contribution of each measure to disease progression which then can be used in the advancement of developing more effective treatment methods or therapeutical approaches targeting the most sensitive measures, to delay the neural degeneration and the subsequent onset of the Huntington’s disease.
Dr Carolina Gubert
EXPLORING THE GUT MICROBIOME AND GENE-ENVIRONMENT INTERACTIONS IN HUNTINGTON’S DISEASE: TOWARDS NOVEL THERAPEUTIC APPROACHES TO DELAY DISEASE ONSET AND PROGRESSION
Research Date: 01/01/2019
Our laboratory has extensively contributed to our understanding of gene-environment interactions in Huntington’s disease (HD), including the beneficial effects of cognitive stimulation and physical activity. Environmental enrichment and exercise interventions mimics a stimulating lifestyle, which has been shown to positively impact different neurodegenerative conditions, including HD, where Anthony Hannan and colleagues made the original discoveries. These approaches have been able to ameliorate neurodegenerative phenotype, emotionality-related behaviours and cognitive effects in HD transgenic mice. We are interested in this project to understand the promising actions of these interventions on the differential gut microbial profile (microbiome) presented in HD mice, also previously discovered by the Hannan Laboratory at the Florey Institute. To achieve this goal, we use cognitive and behavioural tasks, as well as genetics, genomics and bioinformatics tools. These results will be crucial to our understanding of the physiological role of these environmental interventions on gut microbial profile in HD, and will help us identify new therapeutic targets to delay onset and progression of this devastating disease.
REMOTE ASSESSMENT OF COGNITION, SLEEP, AND PHYSICAL ACTIVITY IN EARLY HUNTINGTON'S DISEASE.
Research Date: 01/02/2015
The project is focused on developing technologies that allow greater community participation in Huntington’s disease (HD) research. We are also investigating how the thinking skills of people with HD are affected by how much exercise they do and how well they sleep. We have developed HD mobile, a smartphone application that measures the thinking skills of people who have, or are at risk of developing, HD. HD-Mobile provides HD-community members, regardless of geographical location, the opportunity to participate in HD research. The project will also increase our understanding of how lifestyle (e.g., sleep and exercise) can be managed to boost thinking the performance of people with, or at risk of developing, HD.
We want to investigate a new app which we hope will assist both patients and health professionals to better understand…
Over the past two decades, our research team has played a key role in understanding how the ‘genetic stutter’ causing…
There are currently no effective treatments for apathy (loss of motivation) caused by HD. I am conducting this study to…